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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

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December 9, 2004

Housecleaning

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Posted by Derek

I took the opportunity, while moving to a new project, to clean up my office and files. This time I dug in pretty deeply, and heaved out about 30 pounds of stuff, some of it a good fifteen years old. Looking at the folders, I realized that they were for kinds of chemistry that I hadn't done since then and had no plans to do again. And even if I did, I'd want more current references than these, so out they went.

Good reference papers are a lot less costly to get, in man-hours, than they used to be. Searching manually through Chemical Abstracts meant that when you found something, you held on to it. Who knew if you could find it again? Now, with SciFinder and the like, you can plow through the literature like a nuclear-powered icebreaker. When you find the citation, you hit another button and the PDF hoses right up on your screen. It's like having magic powers, and not many who missed out on the bound-volume days will ever understand how strange it will always feel.

Still, I'm keeping some golden oldies. While my old palladium coupling references are historical artifacts, the ancient papers are still good in some of the slower-moving fields, things like Friedel-Crafts reactions. I still have the first technical paper I ever copied off, from my undergraduate days in 1981, and that one's staying. And the references that are in my PhD thesis are still in their own folder, which is turning a worrisome yellow around the edges.

Comments (2) + TrackBacks (0) | Category: The Scientific Literature


COMMENTS

1. Linkmeister on December 10, 2004 3:18 PM writes...

Scan those early references onto acid-free paper. Don't you know any librarians? ;)

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2. Tree on December 17, 2004 8:54 PM writes...

With the development of IT, the reactions and the starting materials, which are the most important part organic chemistry Ph.D MUST remember, are in your finger tip. Sorry for my broken english.

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