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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline

« Alexander Would Have Understood | Main | Keep It To Yourself »

November 14, 2004

I'll Have the Lot

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Posted by Derek

Thanks to the Patnews mailing list, I was made aware of an alarming patent application from Genentech (WO2004060270, for intellectual property aficianados following along at home.) It's pretty unremarkable, if you just look at the front page. Two inventors, and a bland one-sentence abstract: "The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same."

Generic as can be - that sentence would do, if you were pressed for time, for any of several hundred patent applications that come out every year. Walking around the patent landscape, you'd never stop to pick that one up. But just try it. . .hmmm, seems to be buried in the ground a bit. Dig around, and it's larger than you think. . .you're going to need a shovel to get this thing out. As you go on, this nondescript little pebble turns out to be a bump on the anchor of an entire buried aircraft carrier, and a fleet of diesel-powered backhoes aren't going to be enough to unearth it.

This is just how you feel if you're foolish enough to try to download this thing. My company subscribes to a service called Micropatent, which for a fee gives you access to just about every application and issued patent you could want. Check-mark this one and they cheerfully inform you that it's five thousand and fifty-four pages long. Better make sure that the printer is still under a service contract.

It turns out that this behemoth contains over four thousand gene sequences, presumably the compositions of matter that they're talking about. Now, this would have (almost) made sense eight or ten years ago, in the land-rush era of genomic sequencing. People were flooding patent offices with all kinds of flimsy applications as soon as they got an open reading frame. But a few years ago, the various authorities began to tighten up on this sort of thing.

They wanted to see a lot more enablement of the claims that were coming in - no longer could you say: "I claim gene sequence ATCGAAGTA, etc., and all the diagnostic methods for whatever diseases turn out to be associated with it and any treatments that make someday make use of it and whatever else might end up turning a buck, that too." But that looks like just what Genentech is saying here. The patent has a priority date of October 2002, long after this kind of nonsense was supposed to have packed up.

What's going on? It's no afternoon's work, putting together a five-thousand-page application, and prosecuting it is going to get pretty expensive for a practical joke. I have to presume that they have a reason, but it's hard to see what it might be. The only thing I can think of is that they want to spray down all of these sequences as prior art.

Perhaps Genentech has an idea that there are some useful things in this haystack, but no way to be sure which ones they are. They know, appearances aside, that it's not 1994 any more, and they won't be able to get real patent rights for such a fishing expedition. So if they can't own them, well, here's the way to make sure that no one else can, either. Publish 'em openly, and they're non-patentable. The only problem is that no journal would accept a paper with a title like "Forty-Five Hundred Gene Sequences That Might Be Of Use Someday", with five thousand pages of supplementary material. Heck, they wouldn't have even taken that in 1994.

But the patent office will take it. They'll take most anything if you pay the filing fee, and the application will publish in a year or two no matter how hideous it is. It'll be interesting to watch the prosecution of this one. It's hard to imagine that Genentech is seriously going to take thing thing on and let it nationalize. Nope, my bet is that they're just going to drop it. The mission has already been accomplished.

Comments (4) + TrackBacks (0) | Category: Patents and IP


COMMENTS

1. Peter Ellis on November 14, 2004 7:39 PM writes...

If the intention's to use this as a spoiler and a way to get it in the public domain, why go to the trouble of a patent, why not just publish the sequences in GenBank?

In fact, given that the filing date is after publication of the draft human genome, I'm mystified they got it accepted at all, unless it's >4,000 genes all of which got missed by the sequencing consortium - which *would* be interesting. Chances of that are somewhere between "hmmmm" and "bwahahaha", though.

If this is enforced, enforceable or even meaningful, I'm a monkey's uncle. Someone's just spent a lot of time patenting something that's already known, as far as I can see. It's pissing in the wind.

Permalink to Comment

2. Derek Lowe on November 14, 2004 9:28 PM writes...

The prior art part is also the use of these things in cancer, which wouldn't, I guess, be something that would be addressed in GenBank. But you're right that this application isn't going anywhere, even if (for some reason) Genentech is serious about it.

Permalink to Comment

3. Daniel Newby on November 15, 2004 6:37 PM writes...

Its perfect for legal warfare. If one of their competitors goes after them with a patent using some absurd legal theory, Genentech can pull out this monster and beat them to death with it.

"If the intention's to use this as a spoiler and a way to get it in the public domain, why go to the trouble of a patent, why not just publish the sequences in GenBank?"

Because patent offices keep good back-ups and accurately record priority dates. However if they had just wanted a legally-strong priority date, they could have filed for a statutory invention registration, which is simply a patent without the enforceable monopoly. A monopoly patent means (1) somebody is dumb, (2) there's something hideously valuable hidden in those thousands of pages, or (3) it's a way to countersue. My bet is on #3.

Permalink to Comment

4. Roger James on November 17, 2004 4:56 AM writes...

No surprise at all! In my first job in the chemical industry in the late 70's I worked on an alternative synthesis to nylon. This was simply 'defensive filing' so that the company could claim interests in the alternatives should any company be successful and overturn the venerable Carothers process.
Not really the work for a budding scientist filling up the filing cabinets of some lawyer in HQ. Probably even more toxic than the benzene we were using.

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