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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« A Capacious Rat-Hole Indeed | Main | What Ails Us »

May 23, 2004

Catalyst Catfishing

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Posted by Derek

I've just spent some time shoveling out piles of spam in the comments of my posts, so this will be a short one tonight. Tomorrow I'll head into the lab and take a look at an unusual setup, something I haven't done in quite a while.

I have about thirty small (20 mg) reactions going, all with the same starting materials. They differ only in the metal catalyst I've added, and I went for the most wide-ranging bunch I could find. I have elements in there that I've never even contemplated using before - stuff like indium, tantalum, ytterbium, and praseodymium. It's quite a sight.

Clearly, I have no idea of what I'm doing. Actually, I know the reaction that I'm trying to accelerate, and I have a rough idea of how it might happen. But beyond that, I don't know enough to guess what might work, so I'm just trying everything that looked reasonable (and a few that didn't, frankly, like the tantalum.) You can come across some interesting things this way, but, truth be told, you usually have to run a lot more than thirty variations to find it.

But it's a start, and I'm looking forward to seeing if anything has happened. I feel like a fisherman going off to check his trot lines. What's it going to be? Empty hooks? Tasty fish? Ugly snapping turtle? I'll report back in the next post.

Comments (1) + TrackBacks (0) | Category: Life in the Drug Labs


COMMENTS

1. Linkmeister on May 24, 2004 2:49 PM writes...

You and your Corante colleagues must know about MT-Blacklist, right? Siva, Destroyer of Comment Spam?

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