About this Author
DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: Twitter: Dereklowe

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November 18, 2002


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Posted by Derek

Not much time to blog tonight, and things are busy at work, too. We're wrapping up one project in my lab, trying to start another, and I'm working on a paper about another (older) one. Days like this, my brain needs some new transmission fluid.

I'm still trying to decide where to send the finished paper. Different journals require different levels of experimental detail, and if I want to send this to the Journal of Medicinal Chemistry, where I've never appeared, I'm going to have to round up some more data. Worth it, or not? It depends on how easy it'll be to find all these compounds, which have migrated to distant parts of my lab by now.

For full papers, J. Med. Chem. wants combustion analysis (% of carbon, hydrogen, and oxygen, determined by burning the stuff - a job for a specialty lab) for at least the key compounds. I consider them more trouble than they're worth, although they can help, of course, if you're trying to see if you have a particular salt form or a stable hydrate. By far the majority of combustion analyses I've had to obtain were back during my PhD writeup, and at the rate I'm going, I think I'll be able to say that for the rest of my life. The same goes for optical rotations, and good riddance to those, too. Yep, Mister Purity, that's what they call me around the lab. . .

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