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DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

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In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« Great Moments in Legal Reasoning | Main | Here It Goes »

August 16, 2002

Nature Stood Me Up

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Posted by Derek

. . .not for the first time either, and doubtless not for the last. For anyone stopping by to get an update on my experiment, well, not very much happened. The controls all worked about like I figured they would, but the real experimental cases refused to do anything. And the one run that perhaps moved off the starting point was the one that I least expected to see anything from.

My colleague is going to set up another run in a few days, this one under more forcing conditions (in case I've underestimated the ease that things should occur.) I can come up with a couple of other hypotheses to check as well (as I alluded to this morning.)

But what this means is that (even if my whole concept is right) it isn't going to be easy. It's not like the door is just swinging open to this new field I'm picturing. I'd wondered if it was just because no one had thought to give it a push. I still think the basic idea is sound (although I still have scant evidence for that belief,) but it's an open question how far it can be generalized. If it were as general as I'd hoped, this experiment probably would have worked, frankly.

So, if the door isn't just opening up, the next thing to do is pick the damn lock. I've been uncharacteristically quiet since I got the data today, while I absorbed it and thought about what to do next. But I feel things getting back to normal already. I've got another system to try next week (and I'm working on another new one after that.) And I've had a decent idea to address today's failure, just while sitting here tonight. I'll be back on Monday morning, trying something new. Fortes fortuna juvat.

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