Corante

About this Author
DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: derekb.lowe@gmail.com Twitter: Dereklowe

Chemistry and Drug Data: Drugbank
Emolecules
ChemSpider
Chempedia Lab
Synthetic Pages
Organic Chemistry Portal
PubChem
Not Voodoo
DailyMed
Druglib
Clinicaltrials.gov

Chemistry and Pharma Blogs:
Org Prep Daily
The Haystack
Kilomentor
A New Merck, Reviewed
Liberal Arts Chemistry
Electron Pusher
All Things Metathesis
C&E News Blogs
Chemiotics II
Chemical Space
Noel O'Blog
In Vivo Blog
Terra Sigilatta
BBSRC/Douglas Kell
ChemBark
Realizations in Biostatistics
Chemjobber
Pharmalot
ChemSpider Blog
Pharmagossip
Med-Chemist
Organic Chem - Education & Industry
Pharma Strategy Blog
No Name No Slogan
Practical Fragments
SimBioSys
The Curious Wavefunction
Natural Product Man
Fragment Literature
Chemistry World Blog
Synthetic Nature
Chemistry Blog
Synthesizing Ideas
Business|Bytes|Genes|Molecules
Eye on FDA
Chemical Forums
Depth-First
Symyx Blog
Sceptical Chymist
Lamentations on Chemistry
Computational Organic Chemistry
Mining Drugs
Henry Rzepa


Science Blogs and News:
Bad Science
The Loom
Uncertain Principles
Fierce Biotech
Blogs for Industry
Omics! Omics!
Young Female Scientist
Notional Slurry
Nobel Intent
SciTech Daily
Science Blog
FuturePundit
Aetiology
Gene Expression (I)
Gene Expression (II)
Sciencebase
Pharyngula
Adventures in Ethics and Science
Transterrestrial Musings
Slashdot Science
Cosmic Variance
Biology News Net


Medical Blogs
DB's Medical Rants
Science-Based Medicine
GruntDoc
Respectful Insolence
Diabetes Mine


Economics and Business
Marginal Revolution
The Volokh Conspiracy
Knowledge Problem


Politics / Current Events
Virginia Postrel
Instapundit
Belmont Club
Mickey Kaus


Belles Lettres
Uncouth Reflections
Arts and Letters Daily
In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« Stupidity, But Not the Dangerous Kind | Main | Blowups Happen »

June 24, 2002

Another Shot

Email This Entry

Posted by Derek

Little time to blog tonight - I was out at a celebration of another milestone in a compound's development. I've been to a lot of these over the years, and the reason is that you have to celebrate what things you can. If you wait until the compounds hit the pharmacy shelves, you could be in for a long wait.

I've never worked on a project that's led to an actual product - it's possible to go an entire career without that happening. I can think of one, maybe two of my projects in 13 years that have progressed to having a human being put the compound into their mouth.

What happened to the rest? Most didn't make it to the clinic at all. They ran into trouble early, when we couldn't get improved compounds that were even worth continuing with. Or they ran into trouble late, when we tested then in longer toxicity assays and bad things happened to the rats. Others were recommended for development, but only formally - the project ended, a compound was picked, but by that time the reason for the project's existence had evaporated, and the whole thing died on the vine.

Even the things I've had go up to human trials didn't make it beyond phase I (safety.) I haven't ever had an actual sick person take anything I've worked with; that's Phase II. I'd be happy to speculate on the chances of that happening in the next few years, but only if I could think of a way to do it without giving away information (which I don't think is possible.)

Drug companies guard information about their pipeline very closely, and for the most part the only information that gets made public is what they want their competition (or Wall St.) to see. We all spend time wondering about what the heck the folks are up to at the other companies. . .are they celebrating? Going out to dinner? Still working late at night trying to get that far? Or are they filing away another set of lab notebooks, and starting new ones with another project's title on the spine, hoping that this one will work out, for once. . .

Comments (0) + TrackBacks (0) | Category: Drug Development | Life in the Drug Labs


COMMENTS

EMAIL THIS ENTRY TO A FRIEND

Email this entry to:

Your email address:

Message (optional):




RELATED ENTRIES
Thiola, Retrophin, Martin Shkrell, Reddit, and More
The Most Unconscionable Drug Price Hike I Have Yet Seen
Clinical Trial Fraud
Grinding Up Your Reactions
Peer Review, Up Close and Personal
Google's Calico Moves Into Reality
Reactive Groups: Still Not So Reactive
A VC Firm Touts Its Successes - And Its Failures