About this Author
DBL%20Hendrix%20small.png College chemistry, 1983

Derek Lowe The 2002 Model

Dbl%20new%20portrait%20B%26W.png After 10 years of blogging. . .

Derek Lowe, an Arkansan by birth, got his BA from Hendrix College and his PhD in organic chemistry from Duke before spending time in Germany on a Humboldt Fellowship on his post-doc. He's worked for several major pharmaceutical companies since 1989 on drug discovery projects against schizophrenia, Alzheimer's, diabetes, osteoporosis and other diseases. To contact Derek email him directly: Twitter: Dereklowe

Chemistry and Drug Data: Drugbank
Chempedia Lab
Synthetic Pages
Organic Chemistry Portal
Not Voodoo

Chemistry and Pharma Blogs:
Org Prep Daily
The Haystack
A New Merck, Reviewed
Liberal Arts Chemistry
Electron Pusher
All Things Metathesis
C&E News Blogs
Chemiotics II
Chemical Space
Noel O'Blog
In Vivo Blog
Terra Sigilatta
BBSRC/Douglas Kell
Realizations in Biostatistics
ChemSpider Blog
Organic Chem - Education & Industry
Pharma Strategy Blog
No Name No Slogan
Practical Fragments
The Curious Wavefunction
Natural Product Man
Fragment Literature
Chemistry World Blog
Synthetic Nature
Chemistry Blog
Synthesizing Ideas
Eye on FDA
Chemical Forums
Symyx Blog
Sceptical Chymist
Lamentations on Chemistry
Computational Organic Chemistry
Mining Drugs
Henry Rzepa

Science Blogs and News:
Bad Science
The Loom
Uncertain Principles
Fierce Biotech
Blogs for Industry
Omics! Omics!
Young Female Scientist
Notional Slurry
Nobel Intent
SciTech Daily
Science Blog
Gene Expression (I)
Gene Expression (II)
Adventures in Ethics and Science
Transterrestrial Musings
Slashdot Science
Cosmic Variance
Biology News Net

Medical Blogs
DB's Medical Rants
Science-Based Medicine
Respectful Insolence
Diabetes Mine

Economics and Business
Marginal Revolution
The Volokh Conspiracy
Knowledge Problem

Politics / Current Events
Virginia Postrel
Belmont Club
Mickey Kaus

Belles Lettres
Uncouth Reflections
Arts and Letters Daily
In the Pipeline: Don't miss Derek Lowe's excellent commentary on drug discovery and the pharma industry in general at In the Pipeline

In the Pipeline

« Anything Worth Doing. . . | Main | The Nuts and Bolts of a New Idea »

May 2, 2002

Measure Twice, Cut Once

Email This Entry

Posted by Derek

Not much time to post at the moment, between home life and work. If this were in my single days, I'd be at the lab until all hours working on the ideas I spoke of, but I don't think my two small children would care for that (and I'm certain that my wife wouldn't!) I give her updates on what's going on, though (we used to work at the same pharmaceutical company, and she knows the field.) Actually, I even give my 3 1/2 year old son updates: "Daddy, did you use your stir plate today?" "Yes, I did!" "Did you use your hydraulic hammer?" "My what?" "Did you use a backhoe today, Daddy?" "Um. . ."

I'm involved now in experiment design, trying to make sure that I control for all the possible explanations of what could happen. I find it useful to imagine myself explaining this stuff to the most sceptical/hostile people I've encountered in my scientific career. Picturing what questions they'd ask is a good way to come up with control experiments to make the results stronger.

It's frustrating not to immediately run and set something up, but a few days spent at this point could mean a lot. An experiment that looks like it might be big, but could also be explained by something uninteresting, is almost worse than having a negative result. With a little care up front, I can avoid that situation completely.

Comments (0) + TrackBacks (0) | Category: Birth of an Idea



Email this entry to:

Your email address:

Message (optional):

The Last Post
The GSK Layoffs Continue, By Proxy
The Move is Nigh
Another Alzheimer's IPO
Cutbacks at C&E News
Sanofi Pays to Get Back Into Oncology
An Irresponsible Statement About Curing Cancer
Oliver Sacks on Turning Back to Chemistry